Alanna Quinonez
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Further explanation of the links between hypogonadism and obesity is offered by the hypogonadal-obesity-adipocytokine cycle hypothesis (see Figure 1). This effect can be explained by the action of testosterone in inhibiting lipoprotein lipase and thereby reducing triglyceride uptake into adipocytes (Sorva et al 1988), an action which seems to occur preferentially in visceral fat (Marin et al 1995; Marin et al 1996). It is not possible to measure insulin resistance in patients treated with insulin but five out of ten of these patients had a reduction of insulin dose during the study. Testosterone also produced a significant reduction in insulin resistance, measured by the homeostatic model assessment (HOMA), in the fourteen non-insulin treated patients. Testosterone treatment led to a significant reduction in glycated hemoglobin (HbA1C) and fasting glucose compared to placebo. It was found that physiological treatment doses led to improved insulin resistance, as measured by the gold standard technique using a euglycemic clamp and/or serum glucose and insulin responses during glucose tolerance test. Clinical trials of the effect of testosterone on glucose metabolism in men have occurred in diabetic and non-diabetic populations.
A number of research groups have tried to further define the relationship of testosterone and body composition by artificial alteration of testosterone levels in eugonadal populations. Reductions in free testosterone also correlate with age related declines in fat free mass (muscle mass) and muscle strength (Baumgartner et al 1999; Roy et al 2002). Prospective studies show that testosterone levels predict future development of central obesity (Khaw and Barrett-Connor 1992; Tsai et al 2000). There is no data as yet to confirm that the improvement in bone density with testosterone treatment reduces fractures in men and this is an important area for future study. The meta-analysis also assessed the data concerning changes of bone formation and resorption markers during testosterone treatment.
In conclusion, don’t let low testosterone hold you back; instead, empower yourself with the right tools and strategies to live your best life. In the journey of anti-aging for men, knowledge is power, and taking action can lead to transformative results. With the right knowledge, personalized health strategies, and a focus on nutrition and supplementation, it’s possible to reclaim vitality and enhance quality of life. Dr. Gapin advocates for personalized health screenings that can provide valuable insights into an individual’s hormonal health.
In our clinical experience, the incidence of significant adverse effects with treatment producing physiological testosterone levels is low, and many side effects attributed to testosterone are mainly relevant to supraphysiological replacement. The aim of treatment for hypogonadism is to normalize serum testosterone levels and abolish symptoms or pathological states that are due to low testosterone levels. Epidemiological studies have found a positive association between testosterone levels and mood, and depressed aging males have lower testosterone levels than controls (Barrett-Connor, Von Muhlen et al 1999). It seems that adequate testosterone levels are an important influence on sexual symptoms in the aging male and also influence the response of men to PDE-5 inhibitors, the first line treatment for erectile dysfunction in men. There is increasing interest in the group of patients who fail to respond to treatment with PDE-5 inhibitors and have low serum testosterone levels. A receptor with a short CAG sequence produces greater activity when androgens attach, and men with shorter CAG polymorphisms exhibit androgenic traits, such as preserved bone density (Zitzmann et al 2001) and prostate growth during testosterone treatment (Zitzmann et al 2003).
With testosterone levels in today’s middle-aged men dropping to nearly half of what they were two decades ago, understanding the implications and solutions is crucial for maintaining vitality and overall health. When testosterone levels are supported, many patients experience improved energy, better sleep, more stable mood, and better results from exercise. Older men often experience decreased testosterone levels, leading to reduced muscle mass. Often, anecdotal observations highlight that men with high levels of testosterone look strong (more muscle mass, deep voice, specific male facial features), but also often older for their age. Taking testosterone can improve some health biomarkers in humans, like increasing muscle mass, reducing fat mass, improving libido, and increasing energy.
Just a more complete way of looking at health. We also believe patients deserve honesty. We do not use the term longevity medicine because it sounds trendy to us. And that is exactly why language matters. They want to stay active, attractive, capable, independent, and engaged in their own lives for as long as possible.
A number of research groups have tried to further define the relationship of testosterone and body composition by artificial alteration of testosterone levels in eugonadal populations. Reductions in free testosterone also correlate with age related declines in fat free mass (muscle mass) and muscle strength (Baumgartner et al 1999; Roy et al 2002). Prospective studies show that testosterone levels predict future development of central obesity (Khaw and Barrett-Connor 1992; Tsai et al 2000). There is no data as yet to confirm that the improvement in bone density with testosterone treatment reduces fractures in men and this is an important area for future study. The meta-analysis also assessed the data concerning changes of bone formation and resorption markers during testosterone treatment.
In conclusion, don’t let low testosterone hold you back; instead, empower yourself with the right tools and strategies to live your best life. In the journey of anti-aging for men, knowledge is power, and taking action can lead to transformative results. With the right knowledge, personalized health strategies, and a focus on nutrition and supplementation, it’s possible to reclaim vitality and enhance quality of life. Dr. Gapin advocates for personalized health screenings that can provide valuable insights into an individual’s hormonal health.
In our clinical experience, the incidence of significant adverse effects with treatment producing physiological testosterone levels is low, and many side effects attributed to testosterone are mainly relevant to supraphysiological replacement. The aim of treatment for hypogonadism is to normalize serum testosterone levels and abolish symptoms or pathological states that are due to low testosterone levels. Epidemiological studies have found a positive association between testosterone levels and mood, and depressed aging males have lower testosterone levels than controls (Barrett-Connor, Von Muhlen et al 1999). It seems that adequate testosterone levels are an important influence on sexual symptoms in the aging male and also influence the response of men to PDE-5 inhibitors, the first line treatment for erectile dysfunction in men. There is increasing interest in the group of patients who fail to respond to treatment with PDE-5 inhibitors and have low serum testosterone levels. A receptor with a short CAG sequence produces greater activity when androgens attach, and men with shorter CAG polymorphisms exhibit androgenic traits, such as preserved bone density (Zitzmann et al 2001) and prostate growth during testosterone treatment (Zitzmann et al 2003).
With testosterone levels in today’s middle-aged men dropping to nearly half of what they were two decades ago, understanding the implications and solutions is crucial for maintaining vitality and overall health. When testosterone levels are supported, many patients experience improved energy, better sleep, more stable mood, and better results from exercise. Older men often experience decreased testosterone levels, leading to reduced muscle mass. Often, anecdotal observations highlight that men with high levels of testosterone look strong (more muscle mass, deep voice, specific male facial features), but also often older for their age. Taking testosterone can improve some health biomarkers in humans, like increasing muscle mass, reducing fat mass, improving libido, and increasing energy.
Just a more complete way of looking at health. We also believe patients deserve honesty. We do not use the term longevity medicine because it sounds trendy to us. And that is exactly why language matters. They want to stay active, attractive, capable, independent, and engaged in their own lives for as long as possible.
